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 INVITED REVIEW
Year : 2008  |  Volume : 3  |  Issue : 1  |  Page : 16-29

Epilepsy and cognition


Department of Neurology, The Jaslok Hospital and Research Centre, Mumbai, India

Correspondence Address:
Joy D Desai
1703/B, Lady Ratan Towers, Dainik Shivner Marg, Worli, Mumbai - 400 018
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.40586

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Epilepsy and cognition have a multi-tiered reciprocal relationship. Alteration in cognitive abilities and performance may occur in tandem with persistent seizures in a patient with epilepsy. Age at onset, type of seizures, frequency of seizures, types of underlying epilepsy syndrome, and the underlying pathological brain substrate driving epilepsy may all have variable and independent effects on cognition. Therapeutic intervention with anti-epileptic drugs (AEDs) variably modulates cognitive abilities in a patient with epilepsy. Pathological substrate specific effects can compound the potential negative effects of AEDs on cognition. In this review all these aspects are addressed with an analysis of relevant evidence from peer-reviewed publications.






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