home : about us : ahead of print : current issue : archives search instructions : subscriptionLogin 
Users online: 4078      Small font sizeDefault font sizeIncrease font size Print this page Email this page
Year : 2016  |  Volume : 11  |  Issue : 4  |  Page : 309-315

Value of electroencephalographic monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia

1 Department of Pediatrics, Menoufia University, Al Minufya, Egypt
2 Department of Pediatrics, Benha University, Banha, Egypt
3 Department of Pediatrics, Cairo University, Giza, Egypt
4 Department of Pediatrics, Tanta University, Tanta, Egypt
5 Department of Radiology, Benha University, Banha, Egypt

Correspondence Address:
Hatem Hamed Elshorbagy
Department of Pediatrics, Menoufi a University, Al Minufya
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1817-1745.199467

Rights and Permissions

Background: The values of electroencephalography (EEG) in neonatal hypoxic-ischemic encephalopathy (HIE) during therapeutic hypothermia (TH) are still uncertain. Aims: The aim of this study is to detect EEG background, the prevalence of seizures during cooling, and to determine different EEG patterns that can predict brain injury in magnetic resonance imaging (MRI). Patients and Methods: Thirty-nine newborns with HIE were subjected to TH. Continuous monitoring by video-EEG was carried out throughout cooling and during rewarming. MRI was done for all newborns after rewarming. The predictive value of EEG background for MRI brain injury was evaluated at 6-h intervals during cooling and rewarming. Results: At all-time intervals, normal EEG was associated with no or mild MRI brain injury. At the beginning of cooling, normal background was more predictive of a favorable MRI outcome than at later time points. After 24 h of monitoring, diffuse burst suppression and depressed patterns had the greatest prognostic value. In most patients, a discontinuous pattern was not associated with poor prognosis. Thirty-one percent developed electrical seizures, and 8% developed status epilepticus. Seizures were subclinical in 42%. There is a significant association between duration of seizure patterns detected on the EEG and severity of brain injury on MRI. Conclusions: Continuous EEG monitoring in newborns with HIE under cooling has a prognostic value about early MRI brain injury and identifies electrographic seizures, approximately 50% of which are subclinical. Treatment of clinical and subclinical seizure results in a reduction of the total duration of seizure pattern supports the hypothesis that subclinical seizures should be treated.


Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded132    
    Comments [Add]    
    Cited by others 3    

Recommend this journal