|Ahead of print
Posterior arthrodesis of atlantoaxial joint in congenital atlantoaxial instability under 5 years of age: A systematic review
Nikhil Goyal, Shivkumar Bali, Kaustubh Ahuja, Sunny Chaudhary, Sitanshu Barik, Pankaj Kandwal
Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
|Date of Submission||12-Oct-2020|
|Date of Decision||26-Jan-2021|
|Date of Acceptance||16-Feb-2021|
|Date of Web Publication||11-Oct-2021|
Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh 249203, Uttarakhand.
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Introduction: Atlantoaxial instability (AAI) occurs in a variety of congenital and syndromic conditions. Traditionally, AAI has been treated with the use of semi-rigid fixation in younger children and by rigid fixation in older children. Literature currently lacks any systematic review on rigid fixation in children below 5 years of age with congenital AAI. This literature review aims to analyze the outcomes of posterior arthrodesis in congenital AAI in children. Materials and Methods: A literature search was carried out using PubMed, EMBASE, Google Scholar, and Cochrane database using the following phrases: “atlantoaxial fusion,” “atlantoaxial subluxation,” “atlantoaxial dislocation,” “atlantoaxial rotatory fixation,” “atlantoaxial rotatory dislocation,” and “atlantoaxial rotatory subluxation.”Results: Following the screening of 12,338, 12 articles were included. Total number of patients was 23 with a mean age of 3.7 ± 1.1 years. Common complaints with examination findings, surgical details, outcome, and complications were noted and qualitative analysis was done owing to the absence of any randomized controlled trial and small sample size. Discussion: Management of congenital AAI differs significantly than in adults with diagnosis itself being difficult due to incomplete ossification of bones till 9 years of age. Conservative management may be considered in symptomatic children without any neurological deficit. Surgery is indicated in symptomatic AAI but guidelines are not clear regarding management in asymptomatic children. In cases of AAI presenting as dislocation of the atlantoaxial joint, it is imperative to reduce the joint first before proceeding to posterior arthrodesis. In cases of irreducible atlantoaxial dislocation, odontoidectomy via anterior approach is necessary.
Keywords: Atlantoaxial instability, cervical spine, congenital, posterior atlantoaxial fusion
|How to cite this URL:|
Goyal N, Bali S, Ahuja K, Chaudhary S, Barik S, Kandwal P. Posterior arthrodesis of atlantoaxial joint in congenital atlantoaxial instability under 5 years of age: A systematic review. J Pediatr Neurosci [Epub ahead of print] [cited 2022 Sep 29]. Available from: https://www.pediatricneurosciences.com/preprintarticle.asp?id=327903
| Introduction|| |
Atlantoaxial instability (AAI) occurs in a variety of congenital and syndromic conditions which usually present with neck pain, limitation of motion, or spinal cord compression. These may also present incidentally when radiographs are obtained for some other reason. The instability usually occurs due to ligamentous laxity of the transverse odontoid ligament. It leads to anterior luxation of C1 over C2 leading to spinal cord impingement anteriorly by odontoid process and posteriorly by C1 posterior arch. The peculiarities of the atlantoaxial joint are its complex anatomy, immature and small bony structures in pediatric spine as well as the poor healing associated in these conditions.
Traditionally, AAI has been treated by atlantoaxial arthrodesis with the use of semi-rigid fixation with halo immobilization in younger children and by rigid fixation in older children above the age of 10 years. Rigid fixation techniques like transarticular screw fixation, C1 lateral mass and C2 pedicle screw, and O-C2 fusion is well described for various etiologies in adults with little mention in pediatric age group.,,,The literature currently lacks any systematic review on the same in children below 5 years of age with congenital AAI. The aim of this literature review is to obtain a concise knowledge regarding the outcomes of posterior arthrodesis in congenital AAI in children below 5 years of age.
| Materials and Methods|| |
A literature search was carried out using the online databases PubMed, EMBASE, Google Scholar, and the Cochrane database for all studies published in the English language before July 2020. Four separate searches were carried out using the following phrases: (a) “atlantoaxial fusion,” (b) “atlantoaxial subluxation,” (c) “atlantoaxial dislocation,” (d) “atlantoaxial rotatory fixation,” (e) “atlantoaxial rotatory dislocation,” and (f) atlantoaxial rotatory subluxation. The search was carried out without using any limits. The inclusion criteria of the study were (a) study describing surgical outcome of posterior arthrodesis, (b) study subjects less than 5 years, and (c) congenital etiology of AAI in the study subjects. The studies with the following criteria were excluded (a) case reports, (b) non-English literature, (c) reviews, (d) description of non-congenital etiology, (e) studies describing an additional anterior transoral procedure, and (f) surgical techniques. All the articles were reviewed by two authors (NG, SKB) and matched with the current study criteria as described earlier. Full texts of the eligible studies were retrieved and data were extracted in Microsoft Excel sheets. References of all the studies included were hand searched for any other eligible study. A flow chart using the PRISMA format (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is presented [Figure 1].
| Results|| |
Details of studies included
The initial search led to the screening of 12,338 abstracts and after evaluation, 12 articles were included in the systematic review [Figure 1]. All the studies included were retrospective and Level IV evidence studies. The total number of patients included in this review is 23 with a mean age of 3.7 ± 1.1 years (1.7–5 years) [Table 1]. The ratio of males to females was 1.5:1. The mean follow-up of the cases was 48.4 months (median 28.1 months, range 9–195 months). Owing to the absence of any randomized controlled trial and the small sample size, any quantitative analysis of the data obtained could not be done.
The patients commonly presented with complaints of neck pain with stiffness and torticollis and on examination had signs of myelopathy like gait disturbance and neurological deficit.,,,,,,, Down and Marfan syndrome were commonly associated in these patients.,,, Preoperatively, all the patients underwent dynamic flexion extension radiographs, computed tomography (CT), and magnetic resonance imaging (MRI) of the cervical spine. Patients were also assessed by preoperative angiography in one study to ascertain the location of vertebral artery. The radiographic diagnosis of the patients was one of the following: (1) atlantoaxial rotatory fixation (AARF), (2) atlantoaxial rotatory instability, (3) AAI, and (4) fixed atlantodens interval (ADI). Instability was diagnosed by the presence of increased ADI which ranged from 5 to 14 mm in the various series.,,,, Fixed instability was diagnosed by the CT scans. Two studies measured the diameter of C2 pedicle preoperatively (mean 4.8 mm, range 2.4–6.7 mm).,
The atlantoaxial joint was reduced preoperatively under fluoroscopic guidance followed by halo application and second stage surgery performed for posterior arthrodesis. Rest of the studies relied on intraoperative reduction of the joint. The patients underwent posterior C1-C2 arthrodesis with use of implants like sublaminar wire or pedicle screw or both. Sublaminar wires were used either by Gallie’s or Brook’s technique.,,, Pedicle screws were either used in the form of C1 lateral mass and C2 pedicle screws (Goel Harms construct) or transarticular screws (Magerl technique).,,,, Autogenous bone graft was used from one of the following sites: calvarium, iliac crest, and rib.,,,,,, Intraoperative neuromonitoring was used in two studies during placement of screws., Postoperatively patients were immobilized in a hard cervical collar or a halo brace for a period ranging from 4 to 24 weeks.,,,,,, Two of the studies using transarticular screws as the construct did not use any postoperative immobilization., The arthrodesed spine showed solid fusion in a range of 3 to 6 months.
Anatomic reduction was defined as postoperative ADI < 3 mm, partial reduction as ADI > 3 mm with no spinal cord compression and failure of reduction as ADI > 3 mm with spinal cord compression. In the same study, all the patients achieved anatomic or partial reduction. Japanese Orthopedic Assessment score, Neck Disability Index, ASIA score, and Ranawat score were the objective scores to grade the outcomes.,, All the scores showed a statistically significant improvement. A mean vertical growth of 34% (range 17–50%) was noted in one study after a mean follow-up of 28 months. No deaths were recorded in any of the patients included in this study.
Loss of reduction, subaxial spine instability, C1 arch fracture, pseudoarthrosis, screw loosening, bone graft resorption, and swan neck deformity of the cervical spine were the common complications noted.,,, Bone graft donor site morbidity was noticed when graft was obtained from the iliac crest. The presence of instability of the subaxial spine at follow-up was determined using criteria described by White and Panjabi: measured on resting lateral or flexion–extension radiographs, the horizontal displacement of one vertebra in relation to an adjacent vertebra is greater than 3.5 mm and the angulation is greater than 11° in relation to that of either adjacent vertebra.
| Discussion|| |
Even in the presence of radiological AAI, a limited number of children present with signs and symptoms pertaining to it. This is evident from this study in view of the extremely smaller number of cases of AAI below 5 years of age who required surgical intervention. A large number of cases remain asymptomatic by the age of 5 years. This should lead the surgeon to be extra cautious when managing a syndromic case with regards to the atlantoaxial joint and prompt its radiological screening. The incidence of radiological AAI in syndromic cases varies from 14 to 90% and that of symptomatic AAI is around 1%.,
Cases of congenital AAI usually present with torticollis, progressive spinal cord compression along with neurological and respiratory symptoms. Less commonly, they may present acutely after an episode of trauma. In milder cases, they should be suspected if the child is unable or unwilling to turn his head from one side to another and the clinical examination is not consistent with other common causes of torticollis like congenital muscular torticollis or retropharyngeal infection.
Diagnosis of AAI in children
There are numerous quantified parameters described in literature to diagnose AAI in children. Lateral cervical radiographs and MRI of the cervical spine are currently the important modalities for diagnosis.
- An ADI of more than 5 mm on lateral radiographs indicates instability.
- In extension lateral radiographs, overriding of anterior arch of Atlas More Details over the odontoid may be seen in up to 30% of cases.
- The space available for cord (SAC) is another important parameter to diagnose in congenital AAI in children. It is the distance between posterior aspect of dens and anterior aspect of posterior ring of atlas and SAC less than 13 mm have higher risks of neurological deficit.
- The Steel’s rule of thirds: one-third cord, one-third odontoid, and one-third safe space, remains constant throughout the growth of cervical spine and is an important guide on transverse cuts of MRI.
- The tip of odontoid lies below the basion in both flexion and extension of the cervical spine. Any translation of more than 4 mm is indicative of AAI.
- Swischuk line drawn from posterior ring of C1 to anterior cortex of posterior ring of C3 passing 2 mm or more behind the anterior cortex of posterior ring of C2 is suggestive of AAI.
Associated anomalies in congenital AAI
Congenital AAI is associated with basilar invagination in up to 50% of cases. This may lead to nystagmus due to cerebellar compression and brainstem ischemia due to vertebral artery compression. Unilateral absence of C1 may be noted which may be due to aplasia of the lateral mass or complete absence of hemiatlas leading to torticollis. Aplasia of the odontoid may be complete or partial and is usually an incidental finding. Os odontoideum may be seen but its etiology is currently disputed, whether being traumatic or congenital. Other rarer anomalies include occipitalization of atlas, bifid C1, ossiculum terminale, fusion of vertebral bodies, and hypoplasia of vertebral bodies., Involvement of other musculoskeletal structures may be noted due to the inherent ligamentous laxity in syndromic cases.
AAI refers to loss of stable articulation between the atlas and axis and may be classified according to their etiology, that is, congenital, inflammatory, traumatic, or idiopathic. Congenital causes may include syndromes like Down’s, Goldenhar, Morquio, various dysplasias affecting the musculoskeletal system, and osseous abnormalities in the occipitocervical region due to altered embryology. The initial classification of AAD was given by Greenberg: consisted of 2 groups, reducible and fixed. The current widely used classification is the one devised by Wang et al. It classifies atlantoaxial dislocation into four types: instability (type I), reducible dislocation (type II), irreducible dislocation (type III), and bony dislocations (type IV).
Numerous syndromes like Down’s, Goldenhar, Morquio, and various dysplasias affecting the musculoskeletal system are seen to be associated with AAI. Basilar invagination and ligamentous laxity is frequently associated within these syndromic cases., Conversely, in patients with basilar invagination, AAI should be suspected if any of the following features are present—bifid posterior arch of atlas, os odontoideum, occipitalized atlas, C2-3 or C5-6 fusion, and syringomyelia. Aplasia or hypoplasia of the occipital condyles, odontoid, and atlas should also be looked for in these cases. The AAI in syndromic cases is usually reducible and have lesser severe myelopathy as compared with non-syndromic AAI. These patients are usually associated with higher mortality rates due to cervicomedullary compression and also have narrowed spinal diameter at C1-2 level further aggravating the basilar invagination. In these cases, realignment and reduction may be effective in decompression from posterior approach alone if it is reducible but anterior approach may be needed in case the reduction is not possible from a posterior approach.
Challenges in children less than 5 years
Management of congenital AAI differs significantly than in adults with diagnosis itself being difficult due to incomplete ossification of bones till 9 years of age. Further challenges are due to softer, smaller, and deformed bones in children as well as the fact the fusion may lead to affection of normal growth as well as subaxial misalignment and instability. This misalignment may occur due to factors such as damage to occipitocervical muscles and ligaments during surgery, suboptimal reduction of the joint, compensatory change in subaxial spine secondary to C1-2 fusion, and malposition occurring during postoperative immobilization. The smaller and softer bones of children lead to increased incidence of cortical breach, pedicle fracture, and vertebral artery injury. These difficulties can be better managed by careful preoperative evaluation of the radiographs, CT and MRI which help in better planning with regard to surgical technique being used. For C1 pedicle screw, it is recommended to displace C2 nerve root and transect if necessary, and direct identification of the C1 lateral mass. Similarly, the medial wall of the C2 pedicle exposure is useful for pedicle screw placement. Children usually have a wide space between C1-2 arches, due to which a proper adequate size graft needs to be used. Lateral angulation of atlantoaxial joints, basilar invagination, or spondyloptosis can be seen in up to 35% of children in congenital AAI further complicating the surgical management. Osseous abnormalities like bifid C1 or butterfly C2 can also be seen. The presence of pseudofacets or supernumerary joints also obscure the view of the true joints but these may aid in the reduction of the joint as well as provide increased surface area for fusion. Anomalous vertebral artery maybe present in 5% of patients which makes the surgery more risk prone. These anomalies may pose difficulties to screw placement as they pass directly dorsal to C1 lateral mass. There is also increased incidence of pseudoarthrosis in these children due to postulated factors such as inherent collagen defect and altered immunological response in the initial inflammatory period.
Difficulties during patient positioning and intubation in the operation theater are anticipated challenges which can affect the final outcome. General anesthesia leads to increased joint mobility due to loss of protective reflexes during awake state. To avoid excessive neck movement during intubation, laryngeal mask airways have seen to be a valuable tool aiding in intubation of anesthetized patients. Some authors also suggest use of an endotracheal tube which is two sizes smaller than what normally would have been used. Fiberoptic intubation as well as inline stabilization of the neck can aid in successful intubation with reduced chances of cervical spine injury. Prolonged periods of immobilization may be required in these cases owing to ligamentous laxity. Last but not the least, surgeries for posterior C1-2 arthrodesis involves a lot of fluoroscopic images intraoperatively, which can have a debilitating long-term effect on the child.
Role of conservative management
Conservative management may be considered in symptomatic children without any neurological deficit. These usually consist of cervical halter traction in supine position for 24–48h followed by orthotic immobilization of the cervical spine with active range of motion exercises with regular follow-up to detect any radiological or clinical progression. Children with conditions predisposing to AAI should have their cervical spine screened at 3 to 5 years and advanced imaging considered in case of any discrepancies on radiographs. Controversy exists regarding the participation of asymptomatic children in sports with the Paralympics committee restricting participation by children with radiological instability. It is still unclear whether the susceptible children with ADI greater than 4.5 mm are at increased risk of neurodeficit.
Indications of surgery
Surgery is indicated in symptomatic AAI to prevent respiratory failure, progressive neurodeficit, and death, but guidelines are not clear regarding management in asymptomatic children. Apart from neurodeficit, the literature suggests operative intervention in children if there is persistent ADI greater than 4 mm or persistent deformity for more than 3 months or persistent radiological or clinical signs even after 6 weeks of conservative management.
Role of traction and anterior procedures
In cases of AAI presenting as dislocation of the atlantoaxial joint, it is imperative to reduce the joint first before proceeding to posterior arthrodesis. Traction can be used for reduction because it lengthens and relaxes muscles leading to reduction of the joint into its normal anatomical position. It is either applied preoperatively or more commonly, intraoperatively. Brief skeletal traction for a period of about 10min under general anesthesia can be used before proceeding to the definitive procedure in the same setting. It should begin initially with 7–8% of body weight which can be increased to a maximum of 7kg and monitored by serial lateral imaging. Preoperative traction without general anesthesia is less likely to be successful and usually takes longer time, even if successful. The results of traction for the reduction of atlantoaxial dislocation varies from success rates of 80% to failure rates of up to 80%.
In cases of irreducible atlantoaxial dislocation, odontoidectomy via anterior approach is necessary for complete decompression of the spinal canal. Anterior techniques like transoral anterior release and transoral anterior reduction plate have shown good results in numerous series. Recent advances in endoscopic spinal surgery have enabled odontoidectomy by transnasal, transoral, or retropharyngeal approach. Transoral anterior reduction plate technique is one stage procedure which decompresses the spinal canal as well as fuses the vertebral column anteriorly, making the posterior procedure unnecessary. Studies have shown 100% anatomical reduction and 73.3% improved spinal cord function by this technique. Anterior transarticular fixation is another easier method of reducing irreducible atlantoaxial dislocation with lesser complication rates when compared with anterior plating. However, concerns persist regarding safe screw placement.
Methods of posterior arthrodesis
The earliest method of stabilization of atlantoaxial joint which was semi-rigid involved the Gallie or Sonntag or Brook’s method of wiring along with bone grafting to achieve fusion. The success of these techniques depend hugely on the structural bone graft which provide support to the fixation as well as acts as substrate for fusion. This has fallen out of favor due to need for prolonged immobilization postoperatively, high nonunion rates of upto 30%, and risk of damage to neural and ligamentous structures. Posterior wiring is commonly used today in conjunction with other rigid fixation of atlantoaxial joint in cases requiring revision surgery.
The use of transarticular C1-2 (Magerl construct), C1 lateral mass to C2 pedicle screw (Goel-Harms construct) and C1 pedicle to C2 pedicle constructs are being widely reported in pediatric patients now. They have been used in patients as young as 1.7 years. These techniques do not require rigid immobilization postoperatively and high success rates of fusion when compared with the wiring techniques. They also promote fusion at just one intervertebral level without restricting motion at other cervical spine segments. The advantage of Goel Harms construct is that it is less dependent on the course of vertebral artery when compared with the Magerl technique. The anatomic infeasibility of vertebral artery precluding Magerl technique ranges from 7 to 23% of pediatric patients which can be predicted preoperatively by a CT angiogram., The other advantage is that, reduction of the joint can be achieved after placement of screws in Goel Harms technique, whereas in Magerl technique, the joint has to be anatomically reduced first before safe placement of the screws. On the other hand, the disadvantage of Goel Harms technique are its increased cost due to more number of implants being used and proud profile of the implant. Limited published literature also show good outcomes in unilateral Goel Harms constructs. The venous plexus between C1, C2 lateral mass, and C2 nerve root is inevitably damaged during exposure of C1 lateral mass, which may lead to serious bleeding which is particularly important in children owing to their low blood volume.
Occipitocervical fusion has a role in the management of congenital AAI. It is indicated in cases of concomitant occipitocervical instability and AAI and in cases which require an anterior release for reduction of the atlantoaxial joint. Relative indication for it also includes concomitant basilar invagination, osseous anomaly of C1 and failure of previous atlantoaxial fusion. The construct for this can either be a custom made occipitocervical construct which can be used along with Magerl or Goel Harms technique or screws and rod separately for the occiput.
Choice of graft
The commonest site of graft harvested in the series noted was either from iliac crest or rib. Series reporting on posterior wiring commonly used grafts from these sites. Graft site complications occur in 10–40% of cases in the pediatric population below 5 years. Rigid fixation techniques like Magerl or Goel Harms construct do not usually require any structural graft. These procedures usually use local bone along with graft harvested from the calvarium. Series have also reported the use of allograft or synthetic bone graft material but they are usually expensive and associated with high rates of pseudoarthrosis.
Complications arising out of the procedure can be related to the age of the patient as well as the site of surgery. In view of the pediatric population, fractures of atlas or axis may occur during instrumentation. Graft resorption and loss of reduction due to implant loosening can lead to nonunion at the site which necessitates a revision surgery., Down syndrome has seen to be a significant risk factor for complications in such cases. Long-term possible complications would comprise instability of the subaxial spine and loss of lordosis of the cervical spine., Apart from these, complications like vertebral artery injury, spinal cord injury, infection, and donor site morbidity may occur. Respiratory distress defined as single breath count <10 and single breath hold <10s is one of the single most important factor affecting the morbidity and mortality in congenital AAI. Poor nutritional status, compromised diaphragmatic function and weak respiratory muscles also add to the morbidity and mortality.,
Implications on growth of cervical spine
Maintenance of good spinal alignment and vertical growth can be expected after successful atlantoaxial fusion. Although some studies have noted an increase in cervical lordosis at the rate of 1degree per fused level per year till skeletal maturity. Subaxial kyphosis may be noted in the postoperative period which usually remodels with growth, called as Toyama remodeling. The growth of C2 vertebrae is lower when compared with other vertebrae. The growth of disc height in the fused area is also lesser when compared with the non-fused area.
| Limitations and Conclusion|| |
The major and compelling limitation of this systematic review is the limited number of cases who underwent posterior arthrodesis at atlantoaxial joint. This study only deals with congenital causes, leaving out the infective or inflammatory or traumatic or conditions like os odontoideum, the etiology of which has been in controversy in the recent published literature. Further, the studies included in this review were heterogeneous to a large extent in terms of age and etiology of the AAI. But this study is the first comprehensive review of posterior atlantoaxial arthrodesis in children less than 5 years of age due to any congenital cause.
Patients with congenital cause of AAI may present below 5 years of age with neck pain, limited neck motion, torticollis, or signs of myelopathy. Susceptible syndromic asymptomatic patients should undergo cervical spine screening after 3 years and an increased ADI of more than 5 mm should caution the treating surgeon. Apart from neurodeficit, the literature suggests operative intervention in children if there is persistent ADI greater than 4 mm or persistent deformity for more than 3 months or persistent radiological or clinical signs even after 6 weeks of conservative management. Numerous challenges persist with regard to the pediatric age group in the concerned area. Newer rigid fixation techniques with the use of screws are gaining popularity over semi-rigid fixation using wires.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Menezes AH. Craniocervical developmental anatomy and its implications. Childs Nerv Syst 2008;24:1109-22.
Menezes AH. Craniocervical fusions in children: a review. J Neurosurg Pediatr 2012;9:573-85.
Anderson RC, Kan P, Gluf WM, Brockmeyer DL. Long-term maintenance of cervical alignment after occipitocervical and atlantoaxial screw fixation in young children. J Neurosurg 2006;105:55-61.
Kennedy BC, D’Amico RS, Youngerman BE, McDowell MM, Hooten KG, Couture D, et al
; Pediatric Craniocervical Society. Long-term growth and alignment after occipitocervical and atlantoaxial fusion with rigid internal fixation in young children. J Neurosurg Pediatr 2016;17:94-102.
Ifthekar S, Ahuja K, Mittal S, Sarkar B, Deep G, Thomas W, et al
. Management of neglected upper cervical spine injuries. JOIO [Internet] 2020 [cited Oct. 4, 2020]; Available from: https://doi.org/10.1007/s43465-020-00227-y
de Beer JD, Hoffman EB, Kieck CF. Traumatic atlantoaxial subluxation in children. J Pediatr Orthop 1990;10:397-400.
Yi P, Dong L, Tan M, Wang W, Tang X, Yang F, et al
. Clinical application of a revised screw technique via the C1 posterior arch and lateral mass in the pediatric population. Pediatr Neurosurg 2013;49:159-65.
Doyle JS, Lauerman WC, Wood KB, Krause DR. Complications and long-term outcome of upper cervical spine arthrodesis in patients with down syndrome. Spine (Phila Pa 1976) 1996;21:1223-31.
Park JH, Lee E, Lee JW, Kang Y, Ahn JM, Yeom JS, et al
. Postoperative regression of retro-odontoid pseudotumor after atlantoaxial posterior fixation: 11 years of experience in patients with atlantoaxial instability. Spine2017;42:1763-71.
Nader-Sepahi A, Casey AT, Hayward R, Crockard HA, Thompson D. Symptomatic atlantoaxial instability in down syndrome. J Neurosurg 2005;103:231-7.
Shikata J, Yamamuro T, Mikawa Y, Iida H, Kobori M. Surgical treatment of symptomatic atlantoaxial subluxation in Down’s syndrome. Clin Orthopaed Relate Res 1987;220:111-8.
Shikata J, Yamamuro T, Mikawa Y, Iida H, Kobori M. Atlanto-axial subluxation in down’s syndrome. Int Orthop 1989;13:187-92.
Tauchi R, Imagama S, Ito Z, Ando K, Hirano K, Muramoto A, et al
. Complications and outcomes of posterior fusion in children with atlantoaxial instability. Eur Spine J 2012;21:1346-52.
Zhang YH, Shao J, Chou D, Wu JF, Song J, Zhang J. C1-C2 pedicle screw fixation for atlantoaxial dislocation in pediatric patients younger than 5 years: a case series of 15 patients. World Neurosurg 2017;108:498-505.
Grover PJ, Harris LS, Thompson DNP. Craniovertebral junction fixation in children less than 5 years. Eur Spine J 2020;29:961-9.
Toyama Y, Matsumoto M, Chiba K, Asazuma T, Suzuki N, Fujimura Y, et al
. Realignment of postoperative cervical kyphosis in children by vertebral remodeling. Spine (Phila Pa 1976) 1994;19:2565-70.
Wang J, Vokshoor A, Kim S, Elton S, Kosnik E, Bartkowski H. Pediatric atlantoaxial instability: management with screw fixation. Pediatr Neurosurg 1999;30:70-8.
Yang SY, Boniello AJ, Poorman CE, Chang AL, Wang S, Passias PG. A review of the diagnosis and treatment of atlantoaxial dislocations. Global Spine J 2014;4:197-210.
Pennecot GF, Gouraud D, Hardy JR, Pouliquen JC. Roentgenographical study of the stability of the cervical spine in children. J Pediatr Orthop 1984;4:346-52.
Cattell HS, Filtzer DL. Pseudosubluxation and other normal variations in the cervical spine in children: a study of one hundred and sixty children. JBJS 1965;47:1295-309.
Ghanem I, El Hage S, Rachkidi R, Kharrat K, Dagher F, Kreichati G. Pediatric cervical spine instability. J Child Orthop 2008;2:71-84.
Ebraheim NA, Yang H, Lu J, Biyani A, Yeasting RA. Cartilage and synovium of the human atlanto-odontoid joint. An anatomic and histological study. Acta Anat (Basel) 1997;159:48-56.
Tredwell SJ, Newman DE, Lockitch G. Instability of the upper cervical spine in down syndrome. J Pediatr Orthop 1990;10:602-6.
Swischuk LE. Anterior displacement of C2 in children: physiologic or pathologic. Radiology 1977;122:759-63.
Hosalkar HS, Gerardi JA, Shaw BA. Combined asymptomatic congenital anterior and posterior deficiency of the atlas. Pediatr Radiol 2001;31:810-3.
Kuhns LR, Loder RT, Farley FA, Hensinger RN. Nuchal cord changes in children with os odontoideum: evidence for associated trauma. J Pediatr Orthop 1998;18:815-9.
Ali FE, Al-Bustan MA, Al-Busairi WA, Al-Mulla FA, Esbaita EY. Cervical spine abnormalities associated with down syndrome. Int Orthop 2006;30:284-9.
McKay SD, Al-Omari A, Tomlinson LA, Dormans JP. Review of cervical spine anomalies in genetic syndromes. Spine (Phila Pa 1976) 2012;37:E269-77.
Subin B, Liu JF, Marshall GJ, Huang HY, Ou JH, Xu GZ. Transoral anterior decompression and fusion of chronic irreducible atlantoaxial dislocation with spinal cord compression. Spine (Phila Pa 1976) 1995;20:1233-40.
Greenberg AD. Atlanto-axial dislocations. Brain 1968;91:655-84.
Muthukumar N. Problems in instrumentation of syndromic craniovertebral junction anomalies - case reports. Neurospine 2019;16:277-85.
Sardhara J, Behari S, Jaiswal AK, Srivastava A, Sahu RN, Mehrotra A, et al
. Syndromic versus nonsyndromic atlantoaxial dislocation: do clinico-radiological differences have a bearing on management? Acta Neurochir (Wien) 2013;155:1157-67.
Chatterjee S, Shivhare P, Verma SG. Chiari malformation and atlantoaxial instability: problems of co-existence. Childs Nerv Syst 2019;35:1755-61.
Solanki GA, Lo WB, Hendriksz CJ. MRI morphometric characterisation of the paediatric cervical spine and spinal cord in children with MPS IVA (morquio-brailsford syndrome). J Inherit Metab Dis 2013;36:329-37.
Salunke P, Behari S, Kirankumar MV, Sharma MS, Jaiswal AK, Jain VK. Pediatric congenital atlantoaxial dislocation: differences between the irreducible and reducible varieties. J Neurosurg 2006;104:115-22.
Salunke P, Sahoo SK, Sood S, Mukherjee KK, Gupta SK. Focusing on the delayed complications of fusing occipital squama to cervical spine for stabilization of congenital atlantoaxial dislocation and basilar invagination. Clin Neurol Neurosurg 2016;145:19-27.
Lastikka M, Aarnio J, Helenius I. Instrumented cervical spinal fusions in children: indications and outcomes. J Child Orthop 2017;11:419-27.
Salunke P, Futane S, Sharma M, Sahoo S, Kovilapu U, Khandelwal NK. ‘Pseudofacets’ or ‘supernumerary facets’ in congenital atlanto-axial dislocation: boon or bane? Eur Spine J 2015;24:80-7.
Uchino A, Saito N, Watadani T, Okada Y, Kozawa E, Nishi N, et al
. Vertebral artery variations at the C1-2 level diagnosed by magnetic resonance angiography. Neuroradiology 2012;54:19-23.
Brockmeyer D. Down syndrome and craniovertebral instability. Topic review and treatment recommendations. Pediatr Neurosurg 1999;31:71-7.
Hata T, Todd MM. Cervical spine considerations when anesthetizing patients with down syndrome. Anesthesiology 2005;102:680-5.
Lewanda AF, Matisoff A, Revenis M, Harahsheh A, Futterman C, Nino G, et al
. Preoperative evaluation and comprehensive risk assessment for children with down syndrome. Paediatr Anaesth 2016;26:356-62.
Egol KA, Koval KJ, Zuckerman JD. Handbook of fractures. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2010.
Cohen WI. Current dilemmas in down syndrome clinical care: celiac disease, thyroid disorders, and atlanto-axial instability. Am J Med Genet C Semin Med Genet 2006;142C:141-8.
Song D, Maher CO. Spinal disorders associated with skeletal dysplasias and syndromes. Neurosurg Clin N Am 2007;18:499-514.
Hedequist D, Bekelis K, Emans J, Proctor MR. Single stage reduction and stabilization of basilar invagination after failed prior fusion surgery in children with down’s syndrome. Spine (Phila Pa 1976) 2010;35:E128-33.
Yin QS, Ai FZ, Zhang K, Mai XH, Xia H, Wu ZH. Transoral atlantoaxial reduction plate internal fixation for the treatment of irreducible atlantoaxial dislocation: a 2- to 4-year follow-up. Orthop Surg 2010;2:149-55.
Meals C, Harrison R, Yu W, O’Brien J. Instrumented reduction of a fixed C1-2 subluxation using occipital and C2/C3 fixation: a case report. Int J Spine Surg 2013;7:e20-3.
Guo X, Ni B, Xie N, Lu X, Guo Q, Lu M. Bilateral C1-C2 transarticular screw and C1 laminar hook fixation and bone graft fusion for reducible atlantoaxial dislocation: a seven-year analysis of outcome. PLoS One 2014;9:e87676.
De Iure F, Donthineni R, Boriani S. Outcomes of C1 and C2 posterior screw fixation for upper cervical spine fusion. Eur Spine J 2009;18(Suppl 1):2-6.
Brockmeyer DL, Apfelbaum RI. A new occipitocervical fusion construct in pediatric patients with occipitocervical instability. Technical note. J Neurosurg 1999;90:271-5.
Heuer GG, Hardesty DA, Bhowmick DA, Bailey R, Magge SN, Storm PB. Treatment of pediatric atlantoaxial instability with traditional and modified goel-harms fusion constructs. Eur Spine J 2009;18:884-92.
Stabler CL, Eismont FJ, Brown MD, Green BA, Malinin TI. Failure of posterior cervical fusions using cadaveric bone graft in children. J Bone Joint Surg Am 1985;67:371-5.
Jain VK, Behari S, Banerji D, Bhargava V, Chhabra DK. Transoral decompression for craniovertebral osseous anomalies: perioperative management dilemmas. Neurol India 1999;47:188-95.
] [Full text]
Rodgers WB, Coran DL, Kharrazi FD, Hall JE, Emans JB. Increasing lordosis of the occipitocervical junction after arthrodesis in young children: the occipitocervical crankshaft phenomenon. J Pediatr Orthop 1997;17:762-5.
Parisini P, Di Silvestre M, Greggi T, Bianchi G. C1-C2 posterior fusion in growing patients: long-term follow-up. Spine (Phila Pa 1976) 2003;28:566-72; discussion 572.
Jumah F, Alkhdour S, Mansour S, He P, Hroub A, Adeeb N, et al
. Os odontoideum: a comprehensive clinical and surgical review. Cureus 2017;9:e1551.