Journal of Pediatric Neurosciences
CASE REPORT
Year
: 2015  |  Volume : 10  |  Issue : 2  |  Page : 143--145

A rare case of glycine encephalopathy unveiled by valproate therapy


Velusamy Subramanian1, Pramila Kadiyala2, Praveen Hariharan3, E Neeraj4 
1 Department of Paediatric Neurology, Institute of Social Paediatrics, Stanley Medical College, Chennai, Tamil Nadu, India
2 Department of Biochemistry, Institute of Child Health, Madras Medical College, Chennai, Tamil Nadu, India
3 Intern, Stanley Medical College, Chennai, Tamil Nadu, India
4 Department of Paediatrics, Institute of Social Paediatrics, Stanley Medical College, Chennai, Tamil Nadu, India

Correspondence Address:
Velusamy Subramanian
Department of Paediatric Neurology, Institute of Social Paediatrics, Stanley Medical College, Chennai, Tamil Nadu
India

Glycine encephalopathy (GE) or nonketotic hyperglycinemia is an autosomal recessive disorder due to a primary defect in glycine cleavage enzyme system. It is characterized by elevated levels of glycine in plasma and cerebrospinal fluid usually presenting with seizures, hypotonia, and developmental delay. In our case, paradoxical increase in seizure frequency on starting sodium valproate led us to diagnose GE.


How to cite this article:
Subramanian V, Kadiyala P, Hariharan P, Neeraj E. A rare case of glycine encephalopathy unveiled by valproate therapy.J Pediatr Neurosci 2015;10:143-145


How to cite this URL:
Subramanian V, Kadiyala P, Hariharan P, Neeraj E. A rare case of glycine encephalopathy unveiled by valproate therapy. J Pediatr Neurosci [serial online] 2015 [cited 2022 Oct 6 ];10:143-145
Available from: https://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2015;volume=10;issue=2;spage=143;epage=145;aulast=Subramanian;type=0