Supplementary Figure 2: Photomicrograph (Case 10) on H&E, ×200 (A) architecture is well preserved. Increase in perimysial connective tissue (arrow). Endomysium shows polygonal fibers with internalization of nuclei. (B) H&E, ×400 hypoplastic fibers (solid arrow) are seen randomly distributed among the normal or mildly hypertrophic fibers (dotted arrow). Photomicrograph (Case 10) on enzyme histochemistry with (C) NADH, X200, fiber differentiation is preserved. There is involvement of both fiber type and hypoplastic fibers are predominantly seen to be type I (arrow)